Boeing's chief executive Dave Calhoun will leave the planemaker by the end of this year, the company has said.
Boeing also said that the boss of its commercial airlines division will retire immediately while its chairman will not stand for re-election.
The firm is under pressure after a door panel on a plane blew-out in mid-air in January.
No-one was injured during the incident, but the firm's safety record has come under renewed scrutiny.